DMCA. Copyrighted Work that you can Claim.
Base have 132 550 books.
Search: 


📙 Regenerative medicine technology: on-a-chip applications for disease modeling, drug discovery and personalized medicine by Atala, Anthony; Murphy, Sean V — free pdf


Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery.

This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.



About book:

About file:

  • File size: 30 529 452
  • Format: pdf


Security code:
Download button

Similar books results


Epigenetics in Human Disease
Epigenetics in Human Disease free download by

''This book covers a huge range of topics, from early life effects on adult disease to epigenetic changes occurring with aging and senescence. Especially pertinent are the several chapters on epigenetic treatments for disease including drugs, miRNA/siRNA,...

Pharmaceutical Data Mining: Approaches and Applications for Drug Discovery (Wiley Series on Technologies for the Pharmaceutical Industry)
Pharmaceutical Data Mining: Approaches and Applications for Drug Discovery (Wiley Series on Technologies for the Pharmaceutical Industry) free epub by Konstantin V. Balakin

Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and developmentIn the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical ...

Medicine and Evolution: Current Applications, Future Prospects (Society for the Study of Human Biology)
Medicine and Evolution: Current Applications, Future Prospects (Society for the Study of Human Biology) epub download by Sarah Elton, Paul O'Higgins

Can an evolutionary perspective be integrated in day-to-day practice and is it of value in medical education and training? If so, when and how? Highlighting exciting areas of research into the evolutionary basis of health and disease, Medicine and Evoluti...

Nanotechnology in Regenerative Medicine: Methods and Protocols
Nanotechnology in Regenerative Medicine: Methods and Protocols pdf free by Melba Navarro, Josep A. Planell (auth.), Melba Navarro, Josep A. Planell (eds.)

Nanotechnology plays a key leading role in developing tools able to identify, measure, and study cellular events at the nanometric level as well as in contributing to the disclosure of unknown biological interactions and mechanisms, which opens the door f...

Stem Cells and Cancer Stem Cells, Volume 2: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 2
Stem Cells and Cancer Stem Cells, Volume 2: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 2 epub download by Tomoki Aoyama, Junya Toguchida (auth.), M.A. Hayat (eds.)

As in volume 1 of this series, this volume presents information on stem cells and cancer stem cells; Therapeutic Applications in disease and tissue/organ injury. Methodologies of regenerative medicine and tissue engineering are major components of this vo...

Stem Cells and Cancer Stem Cells, Volume 5: Therapeutic Applications in Disease and Injury
Stem Cells and Cancer Stem Cells, Volume 5: Therapeutic Applications in Disease and Injury download pdf by Anna Pastò, Alberto Amadori, Stefano Indraccolo (auth.), M.A. Hayat (eds.)

It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem...

Nanotechnology in Regenerative Medicine: Methods and Protocols
Nanotechnology in Regenerative Medicine: Methods and Protocols epub download by Melba Navarro, Josep A. Planell (auth.), Melba Navarro, Josep A. Planell (eds.)

Nanotechnology plays a key leading role in developing tools able to identify, measure, and study cellular events at the nanometric level as well as in contributing to the disclosure of unknown biological interactions and mechanisms, which opens the door f...

Platelet-Rich Plasma: Regenerative Medicine: Sports Medicine, Orthopedic, and Recovery of Musculoskeletal Injuries
Platelet-Rich Plasma: Regenerative Medicine: Sports Medicine, Orthopedic, and Recovery of Musculoskeletal Injuries free pdf by José F. Lana, Adam Weglein, Eduardo Vicente, Amanda G. M. Perez (auth.), José Fábio Santos Duarte Lana, Maria Helena Andrade Santana, William Dias Belangero, Angela Cristina Malheiros Luzo (eds.)

Platelet-Rich Plasma (PRP) has gained tremendous popularity in recent years as a treatment option for specialties including Orthopedics, Dentistry, Sports Medicine, Otorhinolaryngology, Neurosurgery, Ophthalmology, Urology, Vascular, Cardiothoracic and Ma...

Multiprocessor System-on-Chip: Hardware Design and Tool Integration
Multiprocessor System-on-Chip: Hardware Design and Tool Integration pdf free by Lionel Torres, Pascal Benoit, Gilles Sassatelli (auth.), Michael Hübner, Jürgen Becker (eds.)

Improving future electronic system performance can only be achieved by exploiting parallelism on all system levels. Multicore architectures offer a better performance/Watt ratio than single core architectures with similar performance. Combining multicore ...

Evacuation Modeling Trends
Evacuation Modeling Trends free download by Arturo Cuesta, Orlando Abreu, Daniel Alvear (eds.)

This book presents an overview of modeling definitions and concepts, theory on human behavior and human performance data, available tools and simulation approaches, model development, and application and validation methods. It considers the data and resea...

How Should Humanity Steer the Future?
How Should Humanity Steer the Future? pdf free by Anthony Aguirre, Brendan Foster, Zeeya Merali (eds.)

The fourteen award-winning essays in this volume discuss a range of novel ideas and controversial topics that could decisively influence the course of human life on Earth. Their authors address, in accessible language, issues as diverse as: enabling our s...

High-Performance Big-Data Analytics: Computing Systems and Approaches
High-Performance Big-Data Analytics: Computing Systems and Approaches epub download by Pethuru Raj, Anupama Raman, Dhivya Nagaraj, Siddhartha Duggirala (auth.)

This book presents a detailed review of high-performance computing infrastructures for next-generation big data and fast data analytics. Features: includes case studies and learning activities throughout the book and self-study exercises in every chapter;...

Bioactive Sphingolipids in Cancer Biology and Therapy
Bioactive Sphingolipids in Cancer Biology and Therapy free epub by Yusuf A. Hannun, Chiara Luberto, Cungui Mao, Lina Marie Obeid (eds.)

This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that co...

Introduction to Fractional and Pseudo-Differential Equations with Singular Symbols
Introduction to Fractional and Pseudo-Differential Equations with Singular Symbols free epub by Sabir Umarov (auth.)

The book systematically presents the theories of pseudo-differential operators with symbols singular in dual variables, fractional order derivatives, distributed and variable order fractional derivatives, random walk approximants, and applications of thes...

Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations
Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations free download by Ellen Hsu, Louis Du Pasquier (eds.)

This volume provides in-depth reviews of model systems that exemplify the arms race in host-pathogen interactions. Somatic adaptations are responsible for the individualization of biological responses to the environment, and the continual struggle between...

Distributed Embedded Controller Development with Petri Nets: Application to Globally-Asynchronous Locally-Synchronous Systems
Distributed Embedded Controller Development with Petri Nets: Application to Globally-Asynchronous Locally-Synchronous Systems download pdf by Filipe de Carvalho Moutinho, Luís Filipe Santos Gomes (auth.)

This book describes a model-based development approach for globally-asynchronous locally-synchronous distributed embedded controllers. This approach uses Petri nets as modeling formalism to create platform and network independent models supporting the use...

Design, User Experience, and Usability: Users and Interactions: 4th International Conference, DUXU 2015, Held as Part of HCI International 2015, Los Angeles, CA, USA, August 2-7, 2015, Proceedings, Part II
Design, User Experience, and Usability: Users and Interactions: 4th International Conference, DUXU 2015, Held as Part of HCI International 2015, Los Angeles, CA, USA, August 2-7, 2015, Proceedings, Part II free pdf by Aaron Marcus (eds.)

The three-volume set LNCS 9186, 9187, and 9188 constitutes the proceedings of the 4th International Conference on Design, User Experience, and Usability, DUXU 2015, held as part of the 17th International Conference on Human-Computer Interaction, HCII 2015...

Human-Computer Interaction: Design and Evaluation: 17th International Conference, HCI International 2015, Los Angeles, CA, USA, August 2-7, 2015, Proceedings, Part I
Human-Computer Interaction: Design and Evaluation: 17th International Conference, HCI International 2015, Los Angeles, CA, USA, August 2-7, 2015, Proceedings, Part I free epub by Masaaki Kurosu (eds.)

The 3-volume set LNCS 9169, 9170, 9171 constitutes the refereed proceedings of the 17th International Conference on Human-Computer Interaction, HCII 2015, held in Los Angeles, CA, USA, in August 2015. The total of 1462 papers and 246 posters presented at ...

Regression Analysis: Unified Concepts, Practical Applications, and Computer Implementation
Regression Analysis: Unified Concepts, Practical Applications, and Computer Implementation download pdf by Bruce Bowerman

Regression Analysis: Unified Concepts, Practical Applications, Computer Implementation is a concise and innovative book that gives a complete presentation of applied regression analysis in approximately one-half the space of competing books. With only the...